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The active substance of Diflucan – fluconazole – has the property effectively suppress the synthesis of sterols in the cell mushrooms. The effectiveness of Diflucan proved against yeasts and yeast-like fungi(Candida spp, Cryptococcus neoformans), fungi(Histoplasma capsulatum, Blastomyces dermatitides), dermatophytes(Trichophyton spp, Microsporum spp), dimorphic forms(Coccidioides immitis). Diflucan sufficiently rapidly absorbed from the digestive system, reaching maximum concentration already after 0.5-1.5 hours after ingestion, food intake does not affect the absorption of Diflucan, a half-life of about 26-30 hours (so it can be used once a day). Fluconazole penetrates well into fluids and tissues, its concentration in cerebrospinal fluid, saliva, bronchial secretion is almost the same as in blood plasma and in the stratum corneum of the skin, the drug accumulates in doses exceeding the concentration in blood. Diflucan does not form active metabolites excreted by the kidneys in practically unchanged form. Effective daily dosage is calculated individually, depending on pathology and severity of the disease. For the treatment of genital candidiasis usually require a single application of Diflucan. Receiving Diflucan for other pathologies should last until the disappearance of objective and subjective symptoms. Patients with low immune status (AIDS, immunosuppressive therapy, cancer) usually require maintenance therapy after completion of primary therapy.

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